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The San Francisco 49ers have three injured quarterbacks on their roster right now, but their starter could be back as early as Week 7.

QB Mac Jones and WR Jauan Jennings will play vs. Buccaneers. Updates on Brock Purdy and Ricky Pearsall ahead of Week 6.

The 49ers lost a massive pass rusher when Nick Bosa suffered a season-ending ACL injury. With Bosa out, that leaves a clear void on the team's defense. That said, San Francisco could look to a formally disgruntled All-Pro defensive end.

Charlotte’s lone score came in the final seconds when backup QB Grayson Loftis found Kaemen Hunter-Gibson for a 16-yard touchdown pass to avoid a shutout.

The San Francisco 49ers are gearing up to face the Tampa Bay Buccaneers in Week 6. The injury crisis continues to plague the franchise heading into another crucial week. Brock Purdy is still out, as is key offensive threat Ricky Pearsall. Mac Jones will likely have limited availability as well.

The San Francisco 49ers continue to deal with huge injuries at the beginning of the 2025 NFL season. Brock Purdy, Jauan Jennings, Ricky Pearsall, George Kittle, and Brandon Aiyuk remain out due to injury. However, the team is getting a huge return for their matchup with the Tampa Bay Buccaneers.

The San Francisco 49ers will be without quarterback Brock Purdy and wide receiver Ricky Pearsall, who are both sidelined with injuries, for their game against the Tampa Bay Buccaneers.

The 49ers are expected to express interest in Bengals defensive end Trey Hendrickson. More at Pro Football Rumors.

The San Francisco 49ers (4-1) visit the Tampa Bay Buccaneers (4-1) Sunday at Raymond James Stadium in Tampa, Florida. Kickoff is scheduled for 4:25 p.m. ET (CBS). Let's analyze BetMGM Sportsbook's NFL odds around the 49ers vs. Buccaneers odds and make our expert NFL picks and predictions for the best bets.

Amid a 4-1 start to the season despite having a roster decimated by injuries, including losing Nick Bosa to a torn ACL, the San Francisco 49ers could pursue a star-level pass-rusher prior to the trade deadline.

Connor Colby has been the 49ers' biggest issue in pass protection, but he has been passable as a run blocker. Now, he gets the Buccaneers defense, which is the best in the NFL at defending the run.