NFL Week 6 picks: Lions upset Chiefs
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49ers, Buccaneers
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NFL power rankings: Eagles, Bills fall behind 49ers, Lions; Patriots, Colts, Broncos leap for Week 6
How do all 32 teams in the NFL stack up against each other coming out of Week 5 of the 2025 NFL regular season? Here's an updated look from best to worst.
The Detroit Lions and San Francisco 49ers tangled in the 2023-24 NFC Championship Game in San Francisco with Coach Dan Campbell’s Lions jumping out to a 24-7 halftime lead and the 49ers responding with 27 fourth quarter points to win by a final score of 34-31.
San Francisco 49ers linebacker Fred Warner appeared on the "Manningcast" on Monday, and he dropped a hilarious line about Lions coach Dan Campbell.
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Pro Picks: Chiefs will beat the Lions in a marquee matchup that still could be a Super Bowl preview
Drake Maye and the Patriots made a statement with a comeback win at Buffalo. They’re not letting the Bills cruise to another AFC East title. Now, Mike Vrabel’s team has to avoid a letdown against the rebuilding Saints. Since 2018, teams in the middle of three-game road trip are 29-12 straight up and 28-13 ATS.
The San Francisco 49ers looked at some quarterback options this week as they deal with injury issues for both Brock Purdy and Mac Jones.
Lions-Ravens was ESPN's most-watched Week 3 Monday Night Football game of all time, and the second-most watched traditional MNF game since 2006.
The 49ers have signed DL Bruce Hector to the team’s practice squad. In order to make room on the practice squad, the team released S Jaylen Mahoney.
The San Francisco 49ers beat the Los Angeles Rams in what looked like an improbable outcome. San Francisco was far more shorthanded than their division rivals due to injuries, but still pulled off the upset. While the team is going to be happy with the win, they will have to evaluate a new slew of injuries .
According to SportsLine's Inside the Lines Team and Projection Model, Philadelphia has much more to lose than to gain on Thursday against New York