This article was originally published on www.si.com/nfl/cardinals as Another Week, Another Heartbreaking Cardinals Collapse. The Arizona Cardinals are now 2-4 on the season following their 31-27 loss to the Indianapolis Colts in Week 6.

Jonathan Taylor’s one-yard touchdown run gave Indianapolis the lead in the fourth quarter, and the Colts withstood a final drive into the red zone by the visiting Arizona Cardinals with less than a minute left to pull out a 31-27 victory on Sunday and improve to 5-1.

The Cardinals signed a new quarterback to the active roster after Kyler Murray was ruled out of the game against the Colts.

Oct 12, 2025; Indianapolis, Indiana, USA; Arizona Cardinals tight end Trey McBride (85) celebrates after scoring a touchdown against the Indianapolis Colts during the third quarter of the game at Lucas Oil Stadium. Mandatory Credit: Trevor Ruszkowski-Imagn Images / Trevor Ruszkowski-Imagn Images

The Indianapolis Colts look to keep up their surprising start when they host the Arizona Cardinals on Sunday, Oct. 12.

The Arizona Cardinals received a much needed makeover in the latest 2-round 2026 NFL mock draft. Upgrading the trenches was the priority.

Arizona Cardinals linebacker Mack Wilson Sr. (2) watches as Indianapolis Colts running back Jonathan Taylor (28) scores a touchdown during a game on Sunday, Oct. 12, 2025, at Lucas Oil Stadium in Indianapolis. The Colts defeated the Cardinals 31-27. / Christine Tannous/IndyStar / USA TODAY NETWORK via Imagn Images