Looking to improve the quality of tools for discovering genomic regulatory regions, researchers at the National Institutes of Health combined Chromatin immunoprecipitation (ChIP) of hyper-acetylated ...

Tauopathies are classified by which tau isoform forms fibrils—those with three microtubule-binding domain repeats (3R), those with four (4R), or those with both. What drives one isoform to aggregate ...

ROCHESTER, Minn. -- Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones. Using nuclear magnetic resonance (NMR) ...

A new gene that controls the completion of meiosis in spermatogenesis has been discovered. Until now, details of the mechanism that inactivates the expression of genes involved in the meiotic program ...

Bromodomain protein 4 (BRD4), a transcriptional regulator, plays a crucial role in autoimmunity, cancer, and inflammatory diseases. 1,2 Researchers found that BRD4 is a protein attached to acetylated ...

Sir2, an enzyme belonging to sirtuins, has been shown to be involved in the deacetylation of proteins. Researchers from the ...

This review is designed by Dr. Yinglan Zhao and written by her PhD students Dr. Lei Tao and Yue Zhou (Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University).