Back mutations, restoring critical non-human residues to retain binding affinity. Computational modeling and in silico tools to predict stability, reduce immunogenic epitopes, and optimize sequences.

Antibodies play a vital role in the immune system by providing protection against foreign invaders, such as bacteria and viruses. Produced by B cells, antibodies are protein molecules that can be ...

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In therapeutic applications, monoclonal antibodies (mAbs) provide highly precise targeting of pathological cells and reduced side effects in treating disease. Experimental mice are widely used models ...

SAN DIEGO, Aug. 21, 2023 /PRNewswire/ -- GemPharmatech is proud to announce the launch of NeoMab™, our independently developed fully antibody gene humanized mouse model, after four years of rigorous ...

BELFAST, Northern Ireland--(BUSINESS WIRE)--Fusion Antibodies plc, experts in antibody engineering and Analytics Engines, an advanced data analytics company, have announced a strategic collaboration ...

Integral Molecular Uses Shotgun Mutagenesis to Germline-Humanize Monoclonal Antibodies Seventy percent of FDA-approved monoclonal antibodies (mAbs) and approximately 66% of mAbs currently in clinical ...

In what may be one of the most important HIV research breakthroughs in years, scientists have discovered a strikingly ...

A research group have succeeded in humanization of mouse antibodies that can neutralize the infection caused by human herpesvirus 6B. The team created ''humanized'' antibodies based on mouse ...

The human anti-mouse antibody (HAMA) reaction limits the therapeutic utility of mouse monoclonal antibodies. Humanization of mouse monoclonal antibodies by genetic engineering can improve the in-vivo ...

An international research team led by the University of Cologne has discovered an antibody that could advance the fight ...