The Bills have reigned over the AFC East for five straight seasons and are off to an excellent start towards a sixth in 2025. Both teams are coming off double-digit victories in Week 4, and the Patriots hope the momentum from their 42-13 beatdown of the Carolina Panthers will carry into tonight's divisional clash.

The Patriots and Bills play Sunday in Week 5 of the 2025 NFL season. It's expected that Patriots left guard Jared Wilson will start after missing last week's game. Defensive tackle Milton Williams, who is currently listed as questionable, is also expected to play.

Drake Maye led the Patriots on a 37-yard drive to set up rookie Andy Borregales’ 52-yard field goal with 15 seconds left, and New England beat the Buffalo Bills 23-20, leaving the NFL without an undefeated team five weeks into the season.

The New Orleans Saints take on the Bills in Buffalo at noon on Sunday with the road team serving as a heavy underdog. This is the place to keep up with the score and live updates. The Bills (3-0) are 14.5-point favorites over the Saints, who are 0-3 entering the game.

New England Patriots quarterback Drake Maye had a new nickname that the NFL gave him during the Sunday night win over the Bills.

The New England Patriots take on the Buffalo Bills in a rivalry matchup in Orchard Park, New York on Sunday Night Football.