Buffalo Bills will face New England Patriots in a Week 5 clash of the 2025 NFL regular season. USA fans can find here complete game information, including kickoff times and streaming options, to ensure they don’t miss a moment of the action.

The New England Patriots, led by quarterback Drake Maye, face the Buffalo Bills, led by quarterback Josh Allen, on Sunday, Oct. 5, 2025 at Highmark Stadium in Erie County.

NFL Week 5 continues with the Buffalo Bills hosting the New England Patriots on Sunday Night Football tonight. Start time, schedule and how to watch.

The Patriots lead the all-time series 79-51-1, but the Bills have won eight of the past 11 meetings. Buffalo is a 7.5-point favorite in the latest Patriots vs. Bills odds from SportsLine consensus, while the over/under for total points scored is 49.

Will the Giants' receivers step up? More success coming for Woody Marks? A lot of points expected in Raiders-Colts? Here's last-minute intel for Week 5.