Week 6 of the 2025 NFL season kicked off with a jaw-dropping upset.

The Arizona Cardinals ' next game is on Sunday on the road against the Indianapolis Colts.

Multiple reports indicate that, at a minimum, the Cardinals are preparing to start Brissett in place of Kyler Murray. ESPN states it more strongly, with a report that Brissett is expected to start. NFL Media reports that the Cardinals are leaving the door open for Murray to play.

The Arizona Cardinals might have to turn to quarterback Jacoby Brissett on Sunday against the Indianapolis Colts.

The Colts have scored 163 points in the first five games, which is second-most in the team’s Indianapolis history, one point behind the 2007 team that featured quarterback Peyton Manning, wide receiv...

Rodgers and the Pittsburgh Steelers (3-1) ready for an AFC North matchup in Week 6 with the Cleveland Browns (1-4) at Acrisure Stadium in Pittsburgh, Pennsylvania.