Adipose tissue dysfunction is central to insulin resistance, and the emergence of type 2 diabetes (T2D) is associated with elevated levels of carbonyl metabolites from glucose metabolism. In this ...

A new research paper was published in Volume 17, Issue 11 of Aging-US on November 14, 2025, titled "Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of ...

BUFFALO, NY — December 12, 2025 — A new research paper was published in Volume 17, Issue 11 of Aging-US on November 14, 2025, titled “Methylglyoxal-induced glycation stress promotes aortic stiffening: ...

The same chemical reaction that makes a piece of freshly toasted bread delicious also happens in our bodies, with far less appetizing consequences. We're talking about the Maillard reaction, where ...

Posttranslational mechanisms play a key role in modifying the abundance and function of cellular proteins. Among these, modification by advanced glycation end products has been shown to accumulate ...

Advanced Glycation End products aren’t visible to the naked eye – and their role in cellular damage and premature ageing shouldn’t be underestimated. 8 March 2022 Skin can be shieled against ...

To maintain organ functions, the proteins in the cells need to be kept in balance (proteostasis). This state is disturbed with increasing age. One possible cause is glycation, in which sugars and ...

The receptor for advanced glycation end products (RAGE) has been demonstrated to play a central role in the pathogenic mechanisms of a growing number of important neurological diseases, including ...