Mouse prostate tumor inhibition via disruption of murine telomerase: In vivo and in vitro data for a new preclinical cancer model No significant financial relationships to disclose. This is an ASCO ...

This is a preview. Log in through your library . Abstract CpG islands (CGIs) are primarily promoter-associated genomic regions and are mostly unmethylated within highly methylated mammalian genomes.

Herein, we characterize the DNA methylome in primary human CD4+ T cells. We map DNA methylation peaks across the genome, and identify genes with promoter region methylation in CD4+ T cells using five ...

Researchers identified 16,379 methylated regions using new search method, according to Nature Genetics. Scientists studying how human chemistry can permanently turn off genes have typically focused on ...

Objectives: Recent molecular studies show that the absence of estrogen receptor (ER) α gene expression in breast cancer is associated with methylation of the CpG island located in the 5′ region and ...

Cancer, as a disease, starts with a change in the genome that results in the downregulation of genes involved in "normal" cell behavior. This genetic change can either be induced by a change in the ...

Epigenetic gene regulation is important for both normal development and disease states. In cancers, aberrant promoter CpG island hypermethylation correlates highly with gene inactivation and can ...

Identifying ERBB2 Activating Mutations in HER2-Negative Breast Cancer: Clinical Impact of Institute-Wide Genomic Testing and Enrollment in Matched Therapy Trials Pediatric adrenocortical carcinomas ...

In a first for the field of epigenomics, scientists at the Baylor College of Medicine (BCM) have demonstrated the feasibility of studying systemic differences in DNA methylation at the population ...