The eukaryotic cell cycle orchestrates the orderly duplication and segregation of genetic material through distinct phases—G₁ (growth and monitoring), S (DNA synthesis), G₂ (preparation for division) ...

The cell cycle is governed by a network of surveillance mechanisms that detect DNA lesions and coordinate repair with progression through G1, S, G2 and M phases. Central to this system are sensor ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

For almost 60 years, scientists have tried to understand why DNA doesn't replicate wildly and uncontrollably every time a cell divides, which happens constantly. Without this process, we would die.

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

Before a cell can divide, it has to precisely duplicate its entire genetic information. However, the DNA in the cell exists as part of a DNA-protein complex known as chromatin. For this purpose, the ...