Using engineered zinc-finger nucleases—DNA-binding proteins that target specific sequences—researchers at a biotechnology company report this week in an advanced online publication in Nature that they ...
Zinc finger nucleases are designed to be like heat-seeking missiles, precisely targeted to find and cut specific sequences of DNA. Occasionally, however, they may snip the wrong spot, causing ...
Gene targeting by homologous recombination in embryonic stem cells is extensively used to generate specific mouse mutants. However, most mammalian species lack tools for targeted gene manipulation.
Zinc finger nucleases (ZFNs) have great potential for translational research and clinical use. Scientists succeeded in the efficient construction of functional ZFNs and the improvement of their genome ...
Zinc finger nucleases (ZFNs) have great potential for translational research and clinical use. Scientists succeeded in the efficient construction of functional ZFNs and the improvement of their genome ...
Resulting animals had permanent heritable mutations, according to paper in Science. A group of scientists report the creation of the first genetically modified rats using Sangamo Biosciences zinc ...
Plasmodium vivax is a major cause of malaria morbidity worldwide yet has remained genetically intractable. To stably modify this organism, we used zinc-finger nucleases (ZFNs), which take advantage of ...
Scientists have developed a gene-repair kit that treats the blood-clotting disorder haemophilia in mice. The technique replaces genes in targeted organs without removing cells from the body, ...
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