The dystrophin gene, which is mutated in Duchenne muscular dystrophy, is the largest human gene. A full spectrum of the gene transcripts has not been fully elucidated yet, although two cryptic exons ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 15 (Apr. 15, 2008), pp. 5797-5802 (6 pages) Accurate pre-mRNA splicing requires primary splicing signals, ...

One of the most long-standing, fundamental mysteries of biology surrounds the poorly understood origins of introns. Introns are segments of noncoding DNA that must be removed from the genetic code ...

Introns are found in eukaryotic species, which includes all members of the fungi, plant, and animal kingdoms. Although introns were first discovered almost 30 years ago, scientists are still asking ...

This is a preview. Log in through your library . Abstract RNA is commonly believed to undergo a number of sequential folding steps before reaching its functional fold, i.e., the global minimum in the ...

Cyclone is a portable gene-switch system that uses acyclovir to reversibly control gene expression with minimal toxicity.

The differential efficacy of docetaxel according to NSCLC histology and therapeutic effect of EGFR-TKIs. Background: Intron 1 of the epidermal growth factor receptor (EGFR) gene contains a polymorphic ...