The Iowa State Cyclones lost to the Colorado Buffaloes in Week 7 of the NCAA football season. Here are the highlights.

Iowa State is a 2.5-point favorite, according to FanDuel Sportsbook. The total is set at 51.5 points. You can watch KCCI's college football show, "Big College Kickoff," live on Very Local at 10:30 a.m. every Saturday through Nov. 29. KCCI sports' Jeff Dubrof will host, with Shannon Ehrhardt live from Iowa City or Ames each week.

Colorado and coach Deion Sanders rebounded from a difficult stretch to defeat No. 21 Iowa State with key plays on offense and defense.

Both frustrated after falling last week, the Colorado Buffaloes and No. 22 Iowa State Cyclones will meet Saturday afternoon at Folsom Field. Colorado,

The Iowa State Cyclones fell to the Cincinnati Bearcats in Week 6. Here is a recap of Iowa State's first loss.

Iowa State Cyclones football suffered its second-straight loss of the season after losing to Colorado on the road on Oct. 11.

Kaidon Salter finally laughed last. Pat Shurmur finally rolled the dice. And CU finally pulled out a close game, at home, against a ranked team.

Iowa State listed 14 players as out ahead of the matchup against Colorado, including defensive backs Jontez Williams, Jeremiah Cooper and Khijohnn Cummings-Coleman – plus defensive back Eddie Lemos. This defense can't afford to lose any more pieces, and if Orange is seriously injured, that will set the Cyclones back severely.

The Iowa State Cyclones (5-1) look to bounce back in a Big 12 Conference matchup with the struggling Colorado Buffaloes (2-4) at Folsom Field.

Travis Hines, Eugene Rapay discuss how Iowa State football can pick itself up after last week loss while the men's basketball team had its media day.