Tsukuba, Japan—Microglia are resident immune cells in the central nervous system that participate in the regulation of brain homeostasis throughout life. In early postnatal stages, microglia regulate ...

The Alzheimer's disease pathological cascade unfolds in the brain over decades, amidst a menagerie of cell types reacting to change. How, and when, does each cell type contribute to the process? A ...

When young donor myeloid cells are transplanted into aging mouse brains, they quickly adopt aging phenotypes. In contrast, old myeloid cells transplanted in young brains take on a more youthful aspect ...

Immune cells in the brain called microglia can partially break down large amyloid plaques characteristic of Alzheimer's disease by latching on to them, forming a sort of external stomach and releasing ...