Northwestern Medicine scientists have discovered how calcium signaling channels in microglia—the primary immune cells of the brain—regulate neuroinflammation and promote the development of behaviors ...

Microglia are primary immune cells that safeguard the mammalian brain, partly by devouring or 'phagocytosing' pathogens and toxic debris. Recent genetic studies have consistently highlighted the role ...

Foralumab reduced microglial activity in people with nonactive SPMS, and this was linked to reductions in proinflammatory ...

Recent studies have shown variation in the gene-expression profile and phenotype of microglia across brain regions and between different age and disease states. But the molecular mechanisms that ...

Dominika Pilat, PhD, and Ana Griciuc, PhD, of the Department of Neurology at Massachusetts General Hospital are the lead and senior authors of a paper published in Neuron, "The Gain-of-Function ...

Abnormal microglial energy metabolism in AD. Translocation of Aβ into microglial mitochondria by the outer membrane translocase (TOM) impairs mitochondrial function and inhibits phagocytosis. TREM2 ...

Announcing a new article publication for BIO Integration journal. Alzheimer's disease (AD) is a neurodegenerative disorder ...

Researchers analyzed thousands of microglia from different brain regions of deceased patients who had been diagnosed with a variety of neuropsychiatric and neurodegenerative disorders. Their results ...

In diseases driven by dysfunctional microglia, could replacing them with healthy versions prevent, or even reverse, pathology? Yes, suggest two papers in the June 18 Neuron. Both describe how mice ...

Tiziana Life Sciences Announces New Biomarker Data Showing Nasal Foralumab Downregulates CSF Inflammation, Upregulates Neuroprotective Pathways, and Correlates with Reduced Microglial Activation on ...