Abnormal microglial energy metabolism in AD. Translocation of Aβ into microglial mitochondria by the outer membrane translocase (TOM) impairs mitochondrial function and inhibits phagocytosis. TREM2 ...

In a recent study published in Cell, researchers examined 152,459 microglial transcriptomes from 443 individuals, identifying 12 transcriptional states and their relationship to Alzheimer's disease ...

The transmembrane protein 119 has a new job. Long known as a marker that distinguishes homeostatic microglia from macrophages and other myeloid cells, the protein also helps clear amyloid from the ...

A study by researchers from Fujita University reveals that hypernatremia enhances NFAT5 and NO production in microglia and minocycline mitigates this response. The image above is a schematic showing ...

Scientists discovered that lowering a specific molecule helps microglia switch into a protective state that quiets brain inflammation in Alzheimer’s. A small group of these cells seems to have an ...

Nestled within the plasma membrane, γ-secretase trims the ends off membrane proteins. Among its 150 known substrates, none is more famous than APP. The protease chews APPs transmembrane domain to spit ...

It all started with genetic data. A gene here, a gene there. Eventually the story became clearer: If scientists are to one day find a cure for Alzheimer's disease, they should look to the immune ...