We've made it to another Thursday, which means it is officially time to kick off Week 6 of the 2025-26 NFL regular season with a primetime showdown in the NFC East. On Thursday Night Football, the New York Giants host the defending Super Bowl champion Philadelphia Eagles at MetLife Stadium.

Chris Vasile breaks down his favorite NFL picks against the spread for Week 6, including the Dallas Cowboys and Atlanta Falcons.

Week 6 of the NFL season features a London game, a Monday Night Football doubleheader, and several key matchups. With all undefeated teams losing last

NFL Week 6 picks, predictions for every NFL game this week, including Rams-Ravens, 49ers-Buccaneers, Bengals-Packers, Lions-Chiefs, Bills-Falcons.

The NFL plays three more games in London to bring its total to 42 matchups since 2007, featuring as part of a record seven international games being played in the 2025 season; watch the Minnesota Vikings against the Cleveland Browns at Tottenham Hotspur Stadium from 2.

When the 2025 NFL schedule came out in May, the Cleveland Browns should have filed a protest and asked the league to redo Week 6, because the Browns have been hit with a brutal scheduling quirk that only one other team in NFL history has ever had to face.

The injury report for the Seattle Seahawks (3-2) ahead of their matchup versus the Jacksonville Jaguars (4-1) includes 10 players. The contest starts at 1 p.m. ET on Sunday, Oct. 12, at EverBank Stadium.