Patrick Mahomes has turned back the clock and is running the football. Our expert SNF predictions have the Chiefs star scampering to paydirt against the Detroit Lions.

The Tennessee Titans (1-4) and Las Vegas Raiders (1-4) clash in a Week 6 battle Sunday. Kickoff from Allegiant Stadium in Las Vegas is set for 4:05 p.m. ET (FOX). Let's analyze BetMGM Sportsbook's NFL odds around the Titans vs. Raiders odds and make our expert NFL picks and predictions for the best bets.

The Denver Broncos and New York Jets meet Sunday for a Week 6 game at Tottenham Hotspur Stadium in London. Kickoff is scheduled for 9:30 a.m. ET.

The Chiefs and Lions are set to tangle in Week 6, and our expert NFL predictions expect Jahmyr Gibbs and Xavier Worthy hitting paydirt!

Now, SportsLine's NFL DFS Optimizer has turned its attention to Sunday's 2025 NFL Week 6 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.

The Seattle Seahawks (3-2) have 10 players on their injury report for their matchup versus the Jacksonville Jaguars (4-1) at EverBank Stadium on Sunday, Oct. 12 at 1 p.m. ET. The Jaguars (4-1) currently have 11 players listed on their report for the week.

A Lions-Chiefs matchup was considered a potential Super Bowl preview when the schedule came out. It still could be considering the state of the AFC. Jared Goff leads a dynamic Lions offense against Patrick Mahomes and the inconsistent Chiefs on Sunday night in Kansas City in one of the biggest games in Week 6.

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