A Week 6 NFL betting guide would cover all bases and help make your betting slip a profitable one. Being aware of statistical trends, recent injuries, how weather affects teams and other factors all should be a part of your NFL betting strategy,

The 49ers (4-1) travel across the country to face the Bucs (4-1), and both teams are coming off entertaining 3-point wins on the road. The 49ers — despite being riddled with injuries on offense — won Thursday night over the Rams as huge underdogs. Mac Jones filled in again for quarterback Brock Purdy and the 49ers offense looked good.

Breaking down the best Week 6 survivor pool options with safe chalk picks, sneaky under-the-radar plays and one high-risk swing. An NFL survivor pool is one of the most popular contests for fans looking to add extra drama to the season.

One of McClure's top NFL DFS picks for Sunday is Rams wide receiver Puka Nacua. The former BYU standout delivered a strong showing for the Rams in 2024 despite missing time, hauling in 79 receptions for 990 yards and 3 touchdowns over 11 games. He has picked up right where he left off and hit the ground running in 2025.