Tampa Bay is a 3.5-point favorite in the latest 49ers vs. Buccaneers odds from SportsLine consensus, while the over/under for total points scored is 46.5. The Buccaneers are -179 money line favorites (risk $179 to win $100),

ESPN NFL insider Adam Schefter reported that Purdy missed practice on Thursday, which means it is unlikely he will be cleared to play this Sunday. "49ers QB Brock Purdy also not practicing today due to his toe injury, putting Mac Jones on track to start Sunday at Tampa," Schefter wrote on X (formerly Twitter).

Charles Woodson, Julian Edelman, Charissa Thompson and Jay Glazer gave their biggest takeaways from this NFL season so far.

Defensive coordinator Robert Saleh believes that one particular rookie has the potential to earn veteran-like status with the 49ers. The 49ers drafted Collins in the second round, and that choice paid dividends in Week 4 against the Los Angeles Rams.

The San Francisco 49ers are off to a hot start this 2025 NFL season, going 4-1 through five weeks of pro football. However, it has also been a brutal run for them injury-wise, with several players missing games.

San Francisco 49ers linebacker Fred Warner appeared on the "Manningcast" on Monday, and he dropped a hilarious line about Lions coach Dan Campbell.