The San Francisco 49ers enter Week 6 holding onto the top seed in the NFC, but that No. 1 spot is in peril after the first half in Tampa Bay. They didn't get off to a good start with quarterback Mac Jones tossing an interception on third down on San Francisco's first offensive series.

Highlights from the Week 6 matchup between the San Francisco 49ers and the Tampa Bay Buccaneers during the 2025 NFL season.

It’ a battle of a couple of 4-1 teams that are looking to make a case as contenders in the NFC as the San Francisco 49ers take on the Tampa Bay Buccaneers.

WR Kameron Johnson catches a 34-yard touchdown pass from QB Baker Mayfield against the San Francisco 49ers in Week 6 of the 2025 NFL season.

San Francisco 49ers kicker Eddy Piñeiro puts the 49ers on the board with a 52-yard field goal against Tampa Bay Buccaneers.

The Indianapolis Colts are one of eight NFL teams with just one loss. Says one national expert: 'Maybe the Colts should be ranked higher. Nothing in their profile indicates this great start has been a fluke.'

Watch QB Baker Mayfield's top highlights from the Tampa Bay Buccaneers 30-19 victory over the San Francisco 49ers.

Los Angeles Rams quarterback Matthew Stafford's best throws from his three touchdown game vs. the San Francisco 49ers during Week 5 of the 2025 NFL season.

Another week and a new set of injuries for the Tampa Bay Buccaneers look to leave them shorthanded when the 4-1 San Francisco 49ers come to town on Sunday.  San

The San Francisco 49ers had some good news on their Week 6 injury report, but it still highlights a slew of problems on the health front as they enter a Week 6 showdown vs. the Tampa Bay Buccaneers.

Los Angeles Rams tight end Davis Allen corrals a 20-yard pass from quarterback Matthew Stafford against the San Francisco 49ers at SoFi Stadium.

Let's take a closer look at the Jaguars vs. Seahawks final Week 6 injury report and the potential impact on the game.