Early in the fourth quarter, Cardinals running back Emari Demercado dropped the football before waltzing into the end zone on a wide-open touchdown, which empowered the Titans offense to march 80 yards for their first touchdown in two weeks. Then, down nine points, the Titans turned a Cardinals interception -- into a Tennessee touchdown.

The Arizona Cardinals blew a 21-6 halftime lead to lose to the Tennessee Titans on a walk-off field goal after two costly turnovers on Sunday.

GLENDALE -- The Arizona Cardinals nearly lost starting quarterback Kyler Murray against the Tennessee Titans with a foot injury suffered in the third quarter. The team first ruled him as questionable before he eventually returned. Backup quarterback Jacoby Brissett was in for Arizona for only a few plays.

The Arizona Cardinals seek their third win of the season and to end their two-game losing streak. They face the 0-4 Tennessee Titans in Week 5, a team struggling mightily on offense. Guard Will Hernandez returns to the starting lineup after a year. Will Johnson returns to the lineup after two games out.

The Tennessee Titans defeated the Arizona Cardinals 22-21 on a Joey Slye field goal with no time remaining for their first win of the season.

The Titans left State Farm Stadium on top, 22-21, celebrating their first win of the 2025 season. How, exactly, did Arizona manage to squander the game to fall to 2-3? Here are the missteps that led to their epic collapse:

The Arizona Cardinals (2-3) led the Tennessee Titans 21-6 at halftime before being outscored 16-0 in the second half.

Arizona Cardinals running back Emari Demercado spoiled a 72-yard touchdown run by dropping the ball at the 1-yard line, resulting in a touchback and Titans possession.