Week 5 of the 2025-26 NFL regular season officially gets underway on Thursday, October 2, with a Thursday Night Football primetime clash featuring the NFC West rival San Francisco 49ers and Los Angeles Rams at SoFi Stadium.

Rounding out the afternoon in the late window for Week 5 will be Tennessee at Arizona, Detroit in Cincinnati, taking on the Bengals, and Washington visiting the West Coast to face the Los Angeles Chargers. It's Week 5, and the NFL is down to its final two undefeated teams in the Eagles and Buffalo Bills.

First, in defense of two games that didn’t make the cut. One of the best Week 5 matchups is the defending champion Eagles against the ascending Denver Broncos, but it features two elite defenses with extra-nasty pass rushes. Worth watching? Definitely. High-scoring? Maybe not.

The Chicago Bears have Sunday off in Week 6 of the 2025 NFL season and will play as part of a doubleheader on Monday Night Football on Oct. 13. The Bears (2-2) travel to face the Washington Commanders (3-2) for a 7:15 p.m. game. The Buffalo Bills and Atlanta Falcons meet in a Monday Night Football game at 6:15 p.m.

Bettors looking for sportsbook promos , betting sites, and where to bet on the NFL for Week 6 can read more below, along with picks for some of the biggest games. Here are the top sportsbook promos for new users ahead of the 2025 Week 6 NFL schedule.

That, along with Trevor Lawrence’s stumbling and bumbling game winner Monday evening, led to yours truly spending Tuesday night rewatching every touchdown through five weeks of 2025. That’s where we begin this week’s “What’s Trending in the NFL” column.