How to Open Excel With Macros Disabled. When used in Microsoft Excel 2010, macros are simply pieces of computer code that get loaded when you launch the software. Normally, macros help you perform ...

If Excel is open, close it. Open a few Excel workbooks and from any open workbook, click the Developer tab and then click Macros in the Macros group.

Click "Disable all macros with notification" if you want to activate macros in Excel 2010 but manually allow them to run.

These days, you can still use macros in Excel, but you need to enable the macro feature to do so. Here's how to enable (and disable) macros.