An innovative CRISPR-Cas12f-based activator system may hold significant potential in the future of gene therapy and biological research, suggest researchers of a new study.

The expression of genes has to be carefully regulated in cells; active genes give cells their identity and ability to function. Epigenetic features are just one way that cells control gene expression, ...

Most people recognize Alzheimer's from its devastating symptoms such as memory loss, while new drugs target pathological aspects of disease manifestations, such as plaques of amyloid proteins. Now a ...

How cells control gene expression by cleaning up their mistakes New research from the University of Chicago shows that alternative splicing plays a much bigger role than expected in controlling ...

A recent study marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells. As a proof-of-concept, the ...

Researchers used AI to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types.

Eukaryotes Require Complex Controls Over Gene Expression While basic similarities in gene transcription exist between prokaryotes and eukaryotes—including the fact that RNA polymerase binds ...

To help achieve more precise control of gene therapy, engineers have designed a new control circuit that can keep gene expression levels within a target range. The method could be used to deliver ...

Gene expression is boosted when mRNA anneals with antisense RNA to form double-stranded RNA, which is exported from the nucleus more quickly than single-stranded RNA.