EMBO Press

Solid trouble: tau and TDP-43 interaction in aggregation and pathology

Both microtubule-binding protein tau and RNA-binding protein TDP-43 have been associated with neurodegenerative diseases, such as Alzheimer’s disease, including in co-pathological deposition with each ...
EMBO Press

From microscopes to maps: enabling a new era of open and reproducible data sharing in intravital imaging

In this issue of The EMBO Journal, Pizzagalli and colleagues present proof-of-principle analyses of immune cell motility ...
EMBO Press

Inhibiting cholesterol synthesis halts rhabdomyosarcoma growth via ER stress and cell cycle arrest

De novo cholesterol biosynthesis is a key metabolic vulnerability in rhabdomyosarcoma. Its inhibition halts cell ...
EMBO Press

A personal journey through academia as a neurodiverse scientist

I recently participated in a collection of interviews for an excellent piece by Julian Nowogrodzki, who presented scientists with ADHD and how we navigate the challenges of academia (Nowogrodzki, 2025 ...
EMBO Press

CTRP9 engages AdipoR1 and promotes T cell glycolysis and immunity

AdipoR1 selectively recognizes adipokine ligands, differentially shaping T-cell immune outcomes. CTRP9 engages AdipoR1 to ...
The EMBO Journal

Glutamine‐utilizing transaminases are a metabolic vulnerability of TAZ/YAP‐activated cancer cells

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The transcriptional regulators TAZ and YAP ...
The EMBO Journal

Direct action of endocrine disrupting chemicals on human sperm

A plethora of endocrine disrupting chemicals (EDCs)—omnipresent in food, household, and personal care products—interfere with various human sperm functions and thus might impair fertilization.
The EMBO Journal

Glutamylation of centrosomes ensures their function by recruiting microtubule nucleation factors

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Centrosomes are tubulin-based organelles that ...
The EMBO Journal

PerturbNet predicts single-cell responses to unseen chemical and genetic perturbations

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Chemical and genetic perturbations, such as ...
The EMBO Journal

Gli1 labels progenitors during chondrogenesis in postnatal mice

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Gli1 + chondrogenic progenitors maintained by ...
The EMBO Journal

Structural basis for the preferential recognition of immature flaviviruses by a fusion‐loop antibody

Flaviviruses are a group of human pathogens causing severe encephalitic or hemorrhagic diseases that include West Nile, dengue and yellow fever viruses. Here, using X‐ray crystallography we have ...
The EMBO Journal

Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4

The isolation of pad4‐2 as a suppressor of RPP5 ‐mediated resistance in Ler as well as the requirement for PAD4 in RPP2 and RPP4 resistance in Col‐0 shows that PAD4 participates in several EDS1 ...