Sir2, an enzyme belonging to sirtuins, has been shown to be involved in the deacetylation of proteins. Researchers from the ...

Sir2, an enzyme belonging to sirtuins, has been effectively involved in the deacetylation of proteins. A tandem allosteric effect of reactant and product is responsible for the efficient deacetylation ...

Acetylation of lysine residues in the tail domain of histone H3 is well characterized, but lysine residues in the histone globular domain are also acetylated. Histone modifications in globular domain ...

Targeting a specialized group of histones is safe and opens new therapeutic opportunities for treating blood cancers. This is the main finding of the latest research by Dr. Marcus Buschbeck and Dr.