The New Orleans Saints take on the Bills in Buffalo at noon on Sunday with the road team serving as a heavy underdog. This is the place to keep up with the score and live updates. The Bills (3-0) are 14.5-point favorites over the Saints, who are 0-3 entering the game.

The New England Patriots, behind young quarterback Drake Maye, handed the Buffalo Bills their first loss of the season on 'Sunday Night Football.'

In a massive AFC East clash on "Sunday Night Football" in Week 5, the New England Patriots defeated the Buffalo Bills. Here's how it happened:

Follow along with score and in-game updates as the Bills host the Saints on Sunday afternoon at Highmark Stadium.

The Miami Dolphins and Buffalo Bills faced off in the Thursday Night Football kickoff to Week 3 of the 2025 NFL season. The AFC East rivals entered the game headed in opposite directions, with Miami looking for their first win of the year while Buffalo was looking to remain undefeated.

The Patriots and Bills play Sunday in Week 5 of the 2025 NFL season. It's expected that Patriots left guard Jared Wilson will start after missing last week's game. Defensive tackle Milton Williams, who is currently listed as questionable, is also expected to play.

Here is everything you need to know about the Bills' schedule for the 2025 season, including TV and streaming options for each game.

SportsLine's computer model simulated Patriots vs. Bills 10,000 times and released its NFL best anytime TD scorers props for Buffalo vs. New England in Week 5 Sunday Night Football