Macromolecular CSPs can report on conformational averaging between free and bound states, and so can be used to extract binding constants for (weakly binding) ligands, as shown in Figure 2B. The ...

In a study published in Nature Methods, a research group developed a highly sensitive proteomics method called peptide-centric local stability assay (PELSA), which enables the simultaneous ...

How the proteins in our bodies bind together to form protein complexes plays a critical role in numerous cell ...

Despite immense progress in quantitative high-throughput proteomics, experimentally verified binding residues remain unknown for most proteins 4. In fact, reliable data remain so sparse to even ...

While scientists still don't fully understand the diverse nature of RNA molecules, it is believed that the proteins binding to them, called RNA-binding proteins, are associated with many types of ...

Methods choice is broad and labs are pushing protocols to address expansive biological questions. “The proteins are what carries out the function, but the RNA is what coordinates the activity of all ...

The accurate determination of protein concentration is a foundational requirement in molecular biology, proteomics, and clinical diagnostics. Choosing the most appropriate protein quantification ...

The term biotinylation refers to the process of binding biotin to either a protein or a nucleic acid, or in some cases to another type of molecule. An antibody is one of these potential targets, a ...