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Drake Maye, Stefon Diggs, and the Patriots showed the rest of the NFL they are on the rise Sunday night, as New England upset the Buffalo Bills at Highmark Stadium, 23-20, on national television.

Expert recap and game analysis of the New England Patriots vs. Buffalo Bills NFL game from October 5, 2025 on ESPN.

Buffalo Bills will face New England Patriots in a Week 5 clash of the 2025 NFL regular season. USA fans can find here complete game information, including kickoff times and streaming options, to ensure they don’t miss a moment of the action.

Stefon Diggs made his return to Buffalo with the New England Patriots on Sunday night, and showed his former team -- and the rest of the NFL -- he's still a stud receiver.

The Patriots lead the all-time series 79-51-1, but the Bills have won eight of the past 11 meetings. Buffalo is a 7.5-point favorite in the latest Patriots vs. Bills odds from SportsLine consensus, while the over/under for total points scored is 49.

A blizzard of team spirit is hovering over the 716 as Buffalo Bills fans prepare for the Buffalo Bills prime time match up against the New England Patriots. Despite what the weather forecast might look like for Sunday’s game,

Wegmans is going beyond the freezer aisle for the big game. The grocer is also selling limited-edition Buffalo Bills Rivalries long-sleeve white T-shirts, designed exclusively for the supermarket chain. Bills Mafia, known as one of the NFL’s most passionate fan bases, is encouraged to wear them on Sunday to help white-out Highmark Stadium.