The Buffalo Bills (3-0) host a struggling New Orleans Saints (0-3) squad on Sunday, September 28, 2025 at Highmark Stadium. The Saints have lost three games in a row. Date: Sept. 28

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It's the New England Patriots vs Buffalo Bills this Sunday at Highmark Stadium in an AFC East thriller. Live coverage begins at 7 PM ET on NBC and Peacock.

The Buffalo Bills have only played the New Orleans Saints 12 times throughout NFL history with the most recent game happening in 2021. Though the Saints are a foe not well-known or studied often by the Bills as a whole, yet they’ll be traveling to Highmark Stadium in Orchard Park, NY to try and salvage their season.

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