Chromosomal instability is a phenomenon characterized by rapid changes in the number and structure of chromosomes during cell division. It is very common in solid tumors and it is linked to the ...

A graduate student's curiosity has uncovered a previously unknown link between two important hallmarks of cancer: chromosomal instability and epigenetic alterations. The resulting study, which was ...

B-cell acute lymphoblastic leukaemia is the most common form of childhood cancer. In this type of cancer, which affects blood cells, one of the most common abnormalities is the presence of cells with ...

Chemotherapy seeks to destroy tumor cells and has been a standard treatment for cancer for decades. However, it doesn't always work. "Chemotherapy is good for some patients, but it's not effective in ...

The paper S.F. Bakhoum et al., “Chromosomal instability drives metastasis through a cytosolic DNA response,” Nature, 553:467-72, 2018. Aneuploidy—the presence of abnormal numbers of chromosomes in a ...

Chromosomal instability is a phenomenon characterized by rapid changes in the number and structure of chromosomes during cell division. It is very common in solid tumors and it is linked to the ...

Genomic instability denotes a heightened tendency for genetic alterations and is recognised as a fundamental hallmark of cancer. Disruption of DNA replication fidelity or repair mechanisms leads to ...

A new tool, ContactTracing, enabled researchers to show that chronic activation of the STING pathway, induced by chromosomal instability (CIN), promotes downstream changes in cellular signaling. This ...

Metastatic prostate cancer remains an incurable lethal disease. Studies indicate that prostate cancer accumulates genomic changes during disease progression and displays the highest levels of ...

In advanced or metastatic prostate cancer (PCa), patients may reach a stage where they do not respond to therapy. This stage is associated with chromosomal instability (CIN) and allow cells, up to a ...

A study conducted by the Development and Growth Control Laboratory at IRB Barcelona sheds light on the contribution of DNA damage to the invasiveness of cancer cells. The discovery challenges the ...

New research finds an unexpected link between chromosomal instability and epigenetic alternations, both of which are hallmarks of cancer -- especially advanced, drug-resistant cancers. A graduate ...