Mapping immune cell interactions in gut tissue reveals changes in ulcerative colitis

In a new study published in Science Immunology, researchers at King's College London looked at a type of tissue important for ...
Nature

A spatial atlas identifies tertiary lymphoid tissue-like structures in DKD

A new study by Bernhard Dumoulin, Katalin Susztak and colleagues provides insights into the spatial organization of cells in diabetic kidney disease (DKD) and identifies a tertiary lymphoid structure ...

Immune cell–fibroblast crosstalk may be the key trigger of autoimmune diseases

In autoimmune disorders, immune cells targeting "self" proteins are mistakenly activated, resulting in abnormal expansion and ...
Nature

IL-22 promotes genesis of small intestinal secretory cells that protect against cholera in mice

Thus, similar to epithelial cell responses, transcriptional responses to V. cholerae infection in lamina propria immune cells were cell type specific and more pronounced in the distal SI. Also, among ...
The American Journal of Managed Care

Legend Biotech’s CAR T-cell Therapy Shows Early Promise in SCLC, Other Tumors

Target selection leverages DLL3’s high tumor-surface expression in SCLC/LCNEC and limited normal-tissue expression, while dnTGFBR2 “armoring” aims to blunt TGF-β–mediated T-cell suppression. Dose ...
eLife

Metabolic support of trained immune responses in myeloid cells

A review of literature regarding trained immunity (TI) differentiates two distinct stages of metabolic immune regulation, with primary metabolic changes influencing early epigenetic adaptations that ...