The San Francisco 49ers will take on the Carolina Panthers on Monday, but they'll be without two players and could have two more miss the game.

El receptor lesionado de los 49ers de San Francisco Brandon Aiyuk vio anulados aproximadamente 27 millones de dólares en dinero prácticamente garantizado en su contrato para el próximo año, en lo que

The Panthers cannot beat the 49ers. Don’t misconstrue that: The Panthers can win on Monday. They have won six times already this season. But they cannot go toe-to-toe with the 49ers, both teams playing their best, and win. And that makes this game the ultimate litmus test for the Niners.

The San Francisco 49ers have a big game against the Carolina Panthers that will swing the playoff odds in a big way, depending on who wins. San Francisco is favored, mostly because the Panthers' passing game is limited. If the 49ers want to win, they essentially just have to shut down one player.

Find single game tickets to the San Francisco 49ers vs. Carolina Panthers NFL Week 12 matchup on Monday, November 24, 2025 at Levi's Stadium.

Jacoby Brissett completed an NFL-record 47 passes, but San Francisco's offense rolled in Purdy's first game in weeks.

Jason Pinnock was benched after Week 5, but he has played 80 snaps in the 49ers' dime look since then. However, he has not been good in that role. Pinnock allowed five catches, including a touchdown, in his expanded role against the Arizona Cardinals. That should signal a time to switch things up, as he was one of the few issues in that game.