Tampa Bay is a 3.5-point favorite in the latest 49ers vs. Buccaneers odds from SportsLine consensus, while the over/under for total points scored is 46.5. The Buccaneers are -186 money line favorites (risk $86 to win $100),

The 49ers just lost 30-19 to the Tampa Bay Buccaneers. The 49ers' record is now 4-2, which is good, but Fred Warner is out for the season with an ankle

ESPN NFL insider Adam Schefter reported that Purdy missed practice on Thursday, which means it is unlikely he will be cleared to play this Sunday. "49ers QB Brock Purdy also not practicing today due to his toe injury, putting Mac Jones on track to start Sunday at Tampa," Schefter wrote on X (formerly Twitter).

The former BYU linebacker who played in all but one of his 122 games since 2018 was carted off the field with a severe ankle injury in the 49ers' 30-19 loss to Tampa Bay.

Defensive coordinator Robert Saleh believes that one particular rookie has the potential to earn veteran-like status with the 49ers. The 49ers drafted Collins in the second round, and that choice paid dividends in Week 4 against the Los Angeles Rams.

The San Francisco 49ers are off to a hot start this 2025 NFL season, going 4-1 through five weeks of pro football. However, it has also been a brutal run for them injury-wise, with several players missing games.

San Francisco 49ers linebacker Fred Warner appeared on the "Manningcast" on Monday, and he dropped a hilarious line about Lions coach Dan Campbell.