The San Francisco 49ers are holding their breath after franchise star Fred Warner went down with an injury early in their matchup against the Tampa Bay Buccaneers.

The 49ers turned in their worst performance of the season on Sunday in Tampa Bay to post their second loss of the season. Sure, there was some yardage from the offense, but the Niners were fooled on critical plays on offense and were gashed on defense.

Fred Warner was carted off of the field during the first quarter of what would ultimately be a 30-19 loss for the team.

A new report from an NFL insider indicates that the San Francisco 49ers are interested in potentially acquiring Trey Hendrickson.

Tough but no dice. The San Francisco 49ers suffered a brutal 30-19 loss to the Tampa Bay Buccaneers. They lost their second game of the season to fall to 4-2. B

Ahead of two road games and a bye week in the next three weeks, the Bucs returned to Raymond James Stadium Sunday afternoon to host the 49ers in a matchup featuring two of the top teams in the NFC and two of the most injured teams in the NFL.

Follow along for live updates from the Los Angeles Rams' Week 5 game against the San Francisco 49ers on Thursday Night Football.

The season-ending injury suffered by All-Pro linebacker Fred Warner was almost incomprehensible to his San Francisco 49ers teammates. "You don't replace Fred Warner."

Former 49ers executive Ran Carthon detailed why Fred Warner's injury is a more significant loss for San Francisco than Nick Bosa's earlier in 2025.

Fred Warner is going to miss the remainder of the season after fracturing and dislocating his right ankle in Week 6.

The San Francisco 49ers got a little good news when they released their list of inactive players for a Week 6 matchup with the Tampa Bay Buccaneers.