Preview the Week 6 matchup between the Tampa Bay Buccaneers and San Francisco 49ers with predictions, odds, over/under, spread, betting lines and more.

The Buccaneers also played on the West Coast. They did the 49ers a favor and knocked off the Seahawks in Seattle, 38-35. Baker Mayfield completed 29 of 33 passes for 379 yards and two touchdowns. Rookie Emeka Egbuka caught seven of those passes for 163 yards.

The San Francisco 49ers (4-1) visit the Tampa Bay Buccaneers (4-1) Sunday at Raymond James Stadium in Tampa, Florida. Kickoff is scheduled for 4:25 p.m. ET (CBS). Let's analyze BetMGM Sportsbook's NFL odds around the 49ers vs. Buccaneers odds and make our expert NFL picks and predictions for the best bets.

Find out how to watch the NFL Week 6 game between the Tampa Bay Buccaneers and San Francisco 49ers, as well as the latest odds and updated injury

The Tampa Bay Buccaneers return home to face off against the San Francisco 49ers in Week 6. The 49ers got a positive injury update on Brock Purdy on Thursday mo

The San Francisco 49ers will take on the Tampa Bay Buccaneers this week. Here's what the experts think will happen on Sunday at Raymond James Stadium

Here we will look at and discuss some bold predictions for the game between the 49ers and the Buccaneers in Week 6 of the 2025 NFL season.