The San Francisco 49ers suffered another big blow with star linebacker Fred Warner sustaining a brutal injury in Week 6.

Tampa Bay is a 3.5-point favorite in the latest 49ers vs. Buccaneers odds from SportsLine consensus, while the over/under for total points scored is 46.5. The Buccaneers are -186 money line favorites (risk $86 to win $100),

Baker Mayfield leads the Tampa Bay Buccaneers against Christian McCaffrey and the San Francisco 49ers today. Find out how to watch this NFL game for free.

Baker Mayfield tossed two touchdowns to help lead the Tampa Bay Buccaneers over the San Francisco in a battle of one loss teams from Raymond James Stadium.

San Francisco 49ers linebacker Fred Warner has left the team's matchup versus the Tampa Bay Buccaneers with a gruesome leg injury.

Here is where the San Francisco 49ers sit in the NFL Week 7 power rankings after their loss to the Tampa Bay Buccaneers.

The Tampa Bay Buccaneers return home to face off against the San Francisco 49ers in Week 6. The 49ers got a positive injury update on Brock Purdy on Thursday mo

ESPN NFL insider Adam Schefter reported that Purdy missed practice on Thursday, which means it is unlikely he will be cleared to play this Sunday. "49ers QB Brock Purdy also not practicing today due to his toe injury, putting Mac Jones on track to start Sunday at Tampa," Schefter wrote on X (formerly Twitter).

Amid a 4-1 start to the season despite having a roster decimated by injuries, including losing Nick Bosa to a torn ACL, the San Francisco 49ers could pursue a star-level pass-rusher prior to the trade deadline.