The Bills' upcoming schedule, which kicks off with the New Orleans Saints visiting Buffalo on Sunday, is about as easy as it comes, on paper. The Saints are winless and coming off an absolute clobbering at the hands of the Seattle Seahawks.

Bills Wire will continue to provide updates throughout the 2025 season. Some teams see a window of opportunity to contend for the postseason while others might be getting an early jump on the NFL Draft. We're tracking all the latest NFL injury news going into Week 6 to help you with your fantasy football lineup.

The Atlanta Falcons (2-2) haven't played in game in two weeks, but they will return in Week 6 to host the Buffalo Bills (4-1) on Monday Night Football. While many consider the Bills to be the best team in the NFL, they were upset by the New England Patriots for their first loss of the season last Sunday.

The first three weeks of the 2025 NFL season have led to quite a favorable situation for the Buffalo Bills, but nothing stands to be as important to the Bills' chances of getting home-field advantage as their Week 1 comeback over the Ravens. As fans ...