The Buffalo Bills certainly didn’t look like the last undefeated in team in the NFL as they played the New England Patriots on Sunday night. Penalty after penalty, missed tackle after missed tackle and mix of dropped balls and receivers failing to get open resulted in Buffalo’s first loss of the season to their AFC East foe.

In Week 5 on "Sunday Night Football," the Bills (4-1) lost 23-20 against the Patriots (3-2) at Highmark Stadium. Buffalo was done in by a couple of mistakes on their own end without a doubt. While the Bills battled to make it close, the Pats were too much, including a huge game from former Bill Stefon Diggs.

The Bills committed 11 penalties but pulled away in the fourth quarter to beat the Saints. Here are the highlights.

Patriots WR Stefon Diggs returns to Buffalo to take on the Bills and Josh Allen in a divisional matchup in primetime. Follow along for all the analysis and highlights from Sunday night's game.

The Buffalo Bills gave their fans the comeback of a lifetime with their "Sunday Night Football" victory over the Baltimore Ravens. Here's how.

Fernando Mendoza is the new No. 1 in USA TODAY Sports' 2026 NFL mock draft, with the Indiana QB sizing up as a possible good fit for the Jets. Oregon QB Dante Moore is building a case to be one of this draft class' top prospects if he decides to declare.

Atlanta's second-round pick has shined in his first professional season, helping the Falcons' defense become one of the elite units in the NFL.

The San Francisco 49ers and the Tampa Bay Buccaneers square off in Week 6 of the NFL regular season. Here's the start time and where to watch.