In Eukaryotes, the primary transcripts of nuclear genes are frequently interrupted by non-coding sequences (introns) which must be excised to generate a translatable mRNA. A dedicated organelle, the ...

Tuberculosis (TB) remains one of the world's most serious public health threats, with approximately one-quarter of the global population infected with Mycobacterium tuberculosis. While most infections ...

We are far from understanding all the rules that govern the process of RNA splicing and defining the sequence information that governs intron definition. In the September 25 Proceedings of the ...

Alternative splicing (AS) is a major contributor to transcriptome and proteome diversity. Evolutionary studies help to address questions that are fundamental to understanding this important process.