Week 6 has plenty of intriguing matchups on deck, and already is off the heels of the New York Giants upsetting the Philadelphia Eagles on Thursday night. That just goes to show you that anything can unfold after kickoff,

We have booming kicker nailing two field goals, a pair of Chiefs WRs doing damage, and two NFC RBs each finding the end zone twice as Week 6 highlighted bets.

It's already Week 6 of the 2025 NFL season. Here's a look at expert predictions, picks against the spread and odds for every game on the schedule.

The Saints picked up their first win of the season last week, beating the New York Giants 26-14 at home as 2.5-point favorites, with the Under (42) cashing. They came back from a 14-3 deficit. QB Spencer Rattler threw an 87-yard TD pass and the defense forced 5 turnovers, returning a fumble for a touchdown.

The Bengals' 38.1% pressured rate ranks as the eighth-highest in the NFL, and against LB Micah Parsons and company, they will struggle to keep drives alive and Flacco upright. Cincinnati has scored 10 or fewer points in 2 of 3 games without Burrow.

Our expert NFL predictions expect Bo Nix to have a big day with his arm when the Broncos meet the Jets in London, England!

The Steelers and Cleveland Browns are playing today in Week 6 of the NFL schedule. Here's how to watch the game.