The San Francisco 49ers suffered another major injury and didn’t have enough to overcome those issues in a Week 6 loss to the Tampa Bay Buccaneers.

The NFL season continues with the Tampa Bay Buccaneers hosting the San Francisco 49ers Sunday. Start time, where to watch, streaming and NFL schedule.

The 49ers vs. Buccaneers game kicks off at 4:25 p.m. ET/1:25 p.m. PT on Sunday, Oct. 12, 2025. The Week 6 game between the ...

Bet Buccaneers vs. 49ers at BetMGM Sportsbook, where new users get up to $1,500 in bonus bets back if their first wager doesn ...

The San Francisco 49ers are preparing for their game against Tampa Bay without their top two quarterbacks healthy enough to throw at practice. Starter Brock Purdy is sidelined with a toe injury and ...

SANTA CLARA -- The 49ers just lost 26-21 to the Jacksonville Jaguars. Now, the 49ers' record is 3-1. Here are their grades for this performance. To be fair, Brock Purdy seemed injured. He had no ...

The San Francisco 49ers defensive coordinator, Robert Saleh, caused a bit of controversy this week when he brought up legal sign-stealing involving Liam Coen, the head coach of the Jacksonville ...

A fiery postgame moment saw coaches Liam Coen and Robert Saleh exchange words following the 49ers-Jaguars clash. The injury-riddled San Francisco 49ers had a chance to advance to 4-0 on the young NFL ...

The Jacksonville Jaguars will face the San Francisco 49ers in Week 4 of the 2025 NFL season. Kickoff is scheduled for 4:05 p.m. ET on Sunday, September 28, 2025, at Levi's Stadium. The game will be ...

The Jacksonville Jaguars defeated the San Francisco 49ers 26-21, improving their record to 3-1. Jacksonville's defense forced five turnovers, extending their league-leading total. A late third-quarter ...