Carolina has a chance to break back into the conversation, and the playoff picture with a win over the 49ers tonight.

Red-hot at 9-2, the Rams look to extend their win streak on the road against a 6-6 Panthers team finding new life on offense.

The Carolina Panthers face the San Francisco 49ers on Monday, Nov. 24, 2025 at Levi’s Stadium in Santa Clara, California.

After a late bye week, the Panthers return to the grind in Week 15 against the Saints, which is the most-winnable game they have left, but also a team that just beat them a few weeks ago. After that they finish the season with an excruciating slog facing the Buccaneers twice with the Seahawks sandwiched in-between.

NFL Week 13 odds, picks, predictions, TV channel, streaming information for Sunday football game between the Los Angeles Rams and Carolina Panthers.

Dave Canales opened his postgame press conference Monday night disappointed but resolute. “Just a game of missed opportunities,” the Carolina Panthers’ head coach said before being prompted by any question. He’s right.

This will surely put them over the top. The Carolina Panthers have announced a pair of moves going into tonight's game with the San Francisco 49ers on ESPN's presentation of Monday Night Football. The Panthers are 6-5 and have a chane to take first place in the NFC South thanks to Tampa's loss to the Los Angeles Rams last night.

Carolina Panthers wide receiver Tetairoa McMillan didn’t sugarcoat anything after Week 12. He openly expressed surprise at his recent surge of dropped passes. “I’m just as surprised as you are for dropping so many balls,” McMillan admitted. He has taken accountability after multiple frustrating miscues.