Head coach Kyle Shanahan told reporters at a Monday press conference that running back Isaac Guerendo is going to miss will ...

Nearly 40 players are brand new to the 49ers’ roster and poised to make their debut in Saturday’s preseason opener against ...

San Francisco 49ers running back Jordan James did not suit up for the 49ers joint practice with the Denver Broncos. The ...

Jawhar Jordan and Isaac Guerendo combined to anchor a surprisingly stout run game during Jeff Brohm's inaugural season as the head coach of the Cardinals, but both backs were selected in the 2024 NFL ...

The preseason is always about depth players being able to find roster spots or starting jobs by showing how well they perform ...

Injuries forced running back Isaac Guerendo and fullback Kyle Juszczyk out of Saturday’s practice at 49ers training camp.

The San Francisco 49ers seem to be off to a rough start with two concerning training camp injuries revealed by Kyle Shanahan.

Last year, the San Francisco 49ers saw their skill-position corps decimated by injuries. Star running back Christian ...

In the fourth quarter, Guerendo departed with a foot injury and Shanahan said the 49ers were gathering information and hoping for the best. “I thought Isaac looked real good today,” Shanahan said.

Isaac Guerendo ’s mother, Jen, realized that early on. She remembers a family gathering at a park in southern Indiana during which the kids had a big race. Isaac was 5 or 6 at the time.