eLife1h
Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins
Sensory experience affects the structure of these tree-like neurites, which, it is assumed, modifies neuronal function, yet the evidence is scarce, and the mechanisms are unknown. To study whether ...
eLife1d
Parabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat
Recent studies suggest that calcitonin gene-related peptide (CGRP) neurons in the parabrachial nucleus (PBN) represent aversive information and signal a general alarm to the forebrain. If CGRP neurons ...
eLife19h
A new pipeline SPICE identifies novel JUN-IKZF1 composite elements
Computational pipeline SPICE systematically screens and predicts novel protein-protein binding complexes including the previously unrecognized global association and functional cooperation between ...
eLife1d
Emergence of Dip2-mediated Specific DAG-based PKC Signalling Axis in Eukaryotes
This is a useful study that adds new data to how different DAG pools influence cellular signaling, and dissects how the enzyme Dip2 modulates the minor lipid signaling DAG pool, which is distinct from ...
eLife1d
Barcode activity in a recurrent network model of the hippocampus enables efficient memory binding
This important work substantially advances our understanding of episodic memory by proposing a biologically plausible mechanism through which hippocampal barcode activity enables efficient memory ...
eLife2d
Aurora kinase A promotes trained immunity via regulation of endogenous S-adenosylmethionine metabolism
MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen ...
eLife3d
A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies
Two anti-transferrin receptor (TfR) nanobodies, V H H123 specific for mouse TfR and V H H188 specific for human TfR (huTfR) were used to track transplants non-invasively by PET/CT in mouse models, ...
eLife3d
Toward Stable Replication of Genomic Information in Pools of RNA Molecules
This important theoretical study examines the possibility of encoding genomic information in a collective of short overlapping strands (e.g., the Virtual Circular Genome (VCG) model). The study ...
eLife3d
DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome
This study addresses fundamental questions surrounding otitis media effusion in Down syndrome, identifying DYRK1A as a key gene involved in the condition. The findings are compelling, highlighting ...
eLife3d
Dissociation of the nuclear basket triggers chromosome loss in aging yeast
In many organisms, aging is a clear risk factor for increased rates of chromosome mis-segregation, the main source of aneuploidy. Here, we report that old yeast mother c ...
eLife2d
Gene discovery sheds light on common ear condition in people with Down syndrome
The gene DYRK1A could be a potential therapeutic target to treat ‘glue ear’ in people with Down syndrome, according to a new study.
eLife2d
Parasite ‘matchmakers’ genetically alter plant cells to attract insects
Researchers have revealed how parasitic phytoplasmas manipulate plant biology to act as matchmakers, boosting male insect appeal by modulating hosts to attract more reproductive females.