The growth rate of the atmospheric abundance of methane (CH 4) reached a record high of 15.4 ppb yr −1 between 2020 and 2022, but the mechanisms driving the accelerated CH 4 growth have so far been ...

The steroidogenic enzyme 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) correlates with tumor aggressiveness, and its inhibitors, biochanin-A (BCA) and the related analogs, have shown antitumor ...

As former EPA and ORD scientists, we argue that dismantling ORD would not only jeopardize human and environmental health, but also weaken American science and global competitiveness. ORD’s vital—yet ...

Vibrio cholerae, known for its pathogenicity in humans, is most commonly a marine microbe that forms biofilms on chitin particles, which it can consume as a source of carbon and nitrogen. Upon ...

Epidermal growth factor receptor (EGFR) overexpression is associated with multiple aggressive solid tumors. Despite recent advances in cancer therapy, and specifically in EGFR-targeted therapy, there ...

The tree of life is dotted with inflection points that changed the course of evolution for some lineages, with vast amounts of morphological diversity and species richness generated in short periods ...

Natural ice plays salient roles in making the Earth habitable and sustainable. Previously overlooked, its role in chemical processes is now of emerging interest, particularly due to the freeze ...

The prostaglandin D2 receptor (DP1) functions as a critical regulator of diverse physiological processes, including sleep–wake cycles, allergic responses, and inflammatory cascades. By determining ...

Greening immediately after etiolated-seedling’s emergence from the soil is critical for plants to initiate their autotrophic life cycle through photosynthesis. The greening process relies on a complex ...

Developing oral biologics has long been a holy grail of protein engineering. Traditional antibodies are large and unstable in the presence of gastrointestinal proteases. Here, we present a strategy to ...

Calcineurin is a highly conserved phosphatase that plays a central role in sensing calcium and governing transcriptional, posttranscriptional, and posttranslational signaling networks. Calcineurin is ...

Physical exercise is known to reduce depression, but the underlying brain mechanisms remain unclear. Based on a chronic restraint stress model in mice, we showed that 4-wk treadmill exercise ...