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📉 Beyond the Benefits: The Side Effects of Antipsychotics ⚖️ Weight gain & metabolic syndrome Some atypical antipsychotics drive weight gain, dyslipidemia, and hypertension. Olanzapine and clozapine carry the highest risk, while aripiprazole and ziprasidone are more metabolically tolerable. These effects stem from central hypothalamic changes that increase hunger, as well as peripheral actions on the liver, pancreas, adipose tissue, and skeletal muscle that disrupt glucose and lipid balance (PM