Regardless of whether someone uses talk therapy or pharmacology, or a combination of the two to achieve relief from depression, ultimately, any relief they experience is the consequence of neural plasticity (also called neuroplasticity), which is essentially changes in the function of neural circuits in the brain and/or body. Brain-derived neurotrophic factor (BDNF) was discovered for its role in promoting the growth, survival, and neuroplasticity of neurons, although it has other roles as well.
Regardless of whether someone uses talk therapy or pharmacolog…
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11K views · 223 reactions | One hypothesis for the mechanism of depression implicates deficits in γ-aminobutyric acid (GABA) and downstream alterations in monoaminergic neurotransmission; this hypothesis is supported by evidence in patients with depression and in patients who have died by suicide. Watch the Quick Take video, then see the trial: https://nej.md/2ku3or7 | The New England Journal of Medicine | Facebook
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